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The degree of inhibition of receptors correlates well with the decrease of self administration of morphine and met phet ine in rats, and may be relevant to the effect of bupropion on nicotine addiction.  wellbutrin xl and pregnancy These active metabolites are further metabolized to inactive metabolites and eliminated through excretion into the urine.  wellbutrin sr and weight loss cirrhosis Anorexia nervosa and bulimia which might lead the patient to have a decreased seizure threshold Severe kidney disease Severe hypertension Anxiety disorders caution, agitated patients Pediatric patients see below Use considerable caution in treating patients where suicide may be a risk Psychosis, as bupropion therapy has a record of worsening and sometimes causing hallucinations, paranoia, and feelings of persecution.  does wellbutrin cause weight gain Some patients may also require less than the normal dosing which usually starts at around mg for the first few weeks and is then switched to the normal mg dosage these patients may be kept on the mg regimen however, some patients are experimentally placed on doses as high and sometimes exceeding, mg day.  wellbutrin xl Scattered abnormalities of liver function tests are noted, without evidence of hepatotoxicity.  wellbutrin side effects weight loss

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